Akademik Veri Yönetim Sistemi
Clinical and Experimental Optometry, cilt.105, sa.8, ss.848-852, 2022 (SCI-Expanded, Scopus)
Clinical Relevance: Vessel density (VD) measurements obtained using swept-source optical coherence tomography angiography (SS-OCTA) of the retinal layers and choriocapillaris have the capacity to demonstrated retinal changes in COVID-19 patients. Background: To investigate VD changes in the retinal layers and choroid using SS-OCTA in patients recovered from COVID-19. Methods: This cross-sectionally designed study was conducted in a single eye centre. The diagnosis of COVID-19 disease was confirmed by a polymerase chain reaction test. Patients who had fully recovered from COVID-19 served as the COVID-19 group, and the control group comprised age- and gender-matched healthy subjects. VD measurements in the superficial and outer retina layers and the choriocapillaris were performed using SS-OCTA. Results: VD measurements in the central fovea and all quadrants of superficial and deep retinal layers, and the choriocapillaris, showed a significant decrease in the COVID-19 group (P < 0.05 for all) compared to the control group. Significant reductions in VD measurements were more prominent in the choriocapillaris when compared to the retinal layers. Mean ferritin and C-reactive protein (CRP) concentrations showed negative correlations with VD measurements in certain quadrants of the deep retinal layer and choriocapillaris. Conclusion: VD reductions occur the superficial and deep retinal layers and choriocapillaris in patients with pre-existing COVID-19. These results suggested the use of SS-OCTA as a microvascular biomarker and an auxiliary technique for the diagnosis and follow-up of COVID-19.