The relation between serum cathepsin D level and carotid intima-media thickness in nondiabetic hypertensive patients

Özkayar N., Akyel F., Barça A. N., Pişkinpaşa S. V., Turhan T., Ateş İ., ...Daha Fazla

Turkish Journal of Medical Sciences, cilt.46, sa.1, ss.13-17, 2016 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 1
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/sag-1410-55
  • Dergi Adı: Turkish Journal of Medical Sciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.13-17
  • Anahtar Kelimeler: Atherosclerosis, Carotid intima-media thickness, Cathepsin D, Hypertension
  • Samsun Üniversitesi Adresli: Hayır

Özet

Background/aim: We aimed to investigate the relation between carotid intima-media thickness (CIMT) and serum cathepsin D level in hypertensive patients. Materials and methods: This was a cross-sectional study of 74 hypertensive patients (22 males and 52 females, with a mean age of 51.86 ± 11.75 years). Serum levels of cathepsin D were measured with an enzyme-linked immunosorbent assay. CIMT measurements were taken from 3 different points: right and left common carotid arteries, bifurcation, and the first 2 cm of the internal carotid artery. Mean CIMT was calculated by averaging the measurements taken 3 times from each carotid artery. Results: Mean CIMT value was 0.76 ± 0.15 mm, and median cathepsin D level was 190.3 (12.8–2681.3) ng/mL. A marked positive correlation was found between cathepsin D levels and CIMT (r = 0.331, P = 0.04). In multivariate linear regression analysis, cathepsin D, albumin levels, and the duration of hypertension were significant predictors of CIMT (P = 0.017, P = 0.008, and P = 0.043, respectively). Conclusions: Increased serum cathepsin D level was found to be associated with CIMT in nondiabetic hypertensive patients.