A child with warfarin resistance: Vitamin K epoxide reductase (VKOR) gene mutation Varfarin direncine neden olan vitamin K epoksit redüktaz (VKOR) gen mutasyonu: Bir vaka takdimi

KESKİN SARILAR Z., DOĞAN H., Büyükavci M.

Cocuk Sagligi ve Hastaliklari Dergisi, cilt.55, sa.3, ss.135-137, 2012 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 55 Sayı: 3
  • Basım Tarihi: 2012
  • Dergi Adı: Cocuk Sagligi ve Hastaliklari Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.135-137
  • Anahtar Kelimeler: VKORC1 gene polymorphism, Warfarin resistance
  • Samsun Üniversitesi Adresli: Hayır

Özet

Warfarin is the most widely used drug for prophylaxis and treatment of venous and arterial thromboembolism because of oral intake and its low price. However, it has a narrow therapeutic range, a high rate of bleeding complications, and highly variable dose adjustment between individuals. Dose adjustment is associated with age, gender, weight, height, body surface area, and CYP2C9 and VKORC1 genetic polymorphisms. We report a patient with heterozygous VKORC1 gene mutation who failed to reach a therapeutic level of international normalized ratio (INR) with warfarin therapy.