Characterizing the intraoperative microelectrode recording-induced microlesion effect on motor symptoms in patients with parkinson's disease undergoing deep brain stimulation of the subthalamic nucleus

AYGÜN D., Dere U. A., Yildiz O., Temel Y., Kocabicak E.

Turkish Neurosurgery, cilt.29, sa.3, ss.430-433, 2019 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 3
  • Basım Tarihi: 2019
  • Doi Numarası: 10.5137/1019-5149.jtn.24348-18.3
  • Dergi Adı: Turkish Neurosurgery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.430-433
  • Anahtar Kelimeler: Deep brain stimulation, Microelectrode recording, Microlesion effect, Parkinson's disease, Subthalamic nucleus
  • Samsun Üniversitesi Adresli: Hayır

Özet

AIM: To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson's disease (PD) who underwent deep brain stimulation of the subthalamic nucleus. MATERIAL and METHODS: MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation. RESULTS: MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p < 0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p < 0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p < 0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p < 0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p > 0.05). CONCLUSION: MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.