Akademik Veri Yönetim Sistemi
Acta Medica Mediterranea, cilt.31, sa.1, ss.161-166, 2015 (SCI-Expanded, Scopus)
Introduction: Among the markers of inflammation, in coronary artery disease neutrophil-lymphocyte ratio has been reported the greatest predictive power for poor outcomes in patients with coronary artery disease. Microvascular perfusion failure due to infarct related artery reduces either myocardial tissue salvage or recovery of myocardial functions. Thrombus aspiration can theoretically protect the microcirculation from distal embolization. The aim of this study was to investigate the relation between the neutrophil- lymphocyte ratio (NLR) and the cardiac enzymes with thrombus aspiration in patients with acute ST segment elevated myocardial infarction (STEMI). Methods: Retrospective data of 350 consecutive patients were evaluated for this study. After exclusions, remaining 163 patients with acute anterior STEMI who had undergone primary PCI were recruited. Results: There was significant negative correlation between thrombus aspiration and peak troponin value (r=-0.18 p=0.031), there was a significant positive correlation between NLR and peak troponin value (r=0.26 p=0.003). In multivariate linear regression analysis, thrombus aspiration and NLR were found to be independent predictors of peak troponin increase in all patients enrolled for the study. Conclusion: NLR is already an available biomarker that provides important information about the inflammatory activity during acute phase of acute coronary syndromes and may help in risk stratification of patients with STEMI beyond conventional risk scores. Thrombus aspiration seems effective in decreasing myocardial injury, which might lead to better in-hospital prognosis. In patients with anterior STEMI, thrombus aspiration and initial lower NLR values may predict less myocardial injury.