Akademik Veri Yönetim Sistemi
Acta Medica Mediterranea, cilt.34, sa.5, ss.1327-1330, 2018 (SCI-Expanded, Scopus)
Introduction: Arginine vasopressin (AVP), a hormone of the hypothalamic-pituitary-adrenal axis, is stimulated by endogenous stress. Copeptin is a glycopeptide derived from a pre-pro-hormone, which directly mirrors AVP levels. Copeptin has been shown to be elevated in various infectious and noninfectious diseases, and in acute pancreatitis. The present study aimed to examine copeptin in mild acute pancreatitis patients and to investigate it as a severity index. Materials and methods: This prospective study included 32 patients admitted to the hospital with mild acute pancreatitis, and 30 healthy volunteers. Independent sample t test and Pearson's correlation test were used for statistical evaluation. Results: Serum copeptin level was 0.539±0.076 ng/mL in mild acute pancreatitis patients and was not statistically significantly different than the control group (0.544±0.061 ng/mL). On correlation analysis serum copeptin level was not associated with the known prognosis factors. Conclusion: Previous studies have found that copeptin may be used as a prognostic factor, but our study could not find an increase in mild acute pancreatitis patients or a correlation between copeptin level and other known prognostic factors. Further studies are needed to use copeptin in diagnosis or prognosis prediction in acute pancreatitis.