Akademik Veri Yönetim Sistemi
Wound Practice and Research, cilt.29, sa.4, ss.238-244, 2021 (ESCI, Scopus)
Background This preliminary study aims to present our experience regarding the efficacy of non-centrifuged autologous fat graft in the treatment of lower extremity ulcers. Methods A total of 16 ulcers from 16 cases were retrospectively analysed. VAC (vacuum-assisted therapy) or silver-impregnated dressings were used to achieve a healthy wound bed before fat grafting. Autologous fat graft was harvested from the patients’ abdominal or gluteal regions and injected into the wound edge, wound bed and surrounding environment. Clinical observation and photographic records were used to analyse the ulcers. Results The mean age was 55.88±9.71 years old; 52 years old (range: 44–65.5) for venous ulcers, 57 years old (range: 51–63) for diabetic ulcers and 49.5 years old (range: 45–54) for traumatic ulcers. Of the cases, nine were male. Twelve ulcers needed a skin graft or flap surgery, and four had secondary healing. At the beginning, the mean wound surface area was 92.69±62.74cm2; 125cm2 (range: 52–175) for venous ulcers, 100cm2 (range: 25–112) for diabetic ulcers and 81cm2 (range: 42–120) for traumatic ulcers. The mean number of fat injection procedures was 1.63±0.89, and the mean fat volume used was 26.56±15.33cc. The mean healing time was 32.56±12.03 days. The ulcers were deemed uneventful in the following 12-month period. Conclusion It can be determined that non-centrifuged autologous fat graft is a quite effective and useful method in reducing the treatment time for lower extremity ulcers.