Akademik Veri Yönetim Sistemi
Hellenic Journal of Nuclear Medicine, cilt.26, sa.1, ss.47-56, 2023 (SCI-Expanded, Scopus)
Objective: Discovery of diuse lymphadenopathy (DLAP) in uorine-18-uorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) imaging alerts for the existence of many patho-logic conditions with severity ranging from benign to malignancy.This study examines the role of various metabolic parameters reecting 18F-FDG characteristics of organs/tissues to reach an accurate dierential diagnosis for further clinical assessment. Materials and Methods: Positron emission tomography/CT images of 78 patients with DLAP were reviewed retrospectively. The diameter of the largest lymph node (DLlyn), maximum standardized uptake value (SUVmax) of the liver (L), the largest lymph node (Llyn), spleen (S), and bone marrow (BM) were measured. Ratios to liver SUVmax were calculated for all, resulting LLRmax, SLRmax, and BMLRmax respectively. Results: The diameter of the largest lymph node, Llyn. SUVmax, LLRmax, and SLRmax produced cut-o values as 25.5, 8.86, 2.80, and 0.82 with corresponding sensitivity: specicity values as 65%:83%, 74%:77%, 74%:71%, and 79%:63% respectively for risk stratication of malignant causes.To dierentiate lymphoma from sarcoidosis, DLlyn, SLRmax, and BMLRmax were found valuable with cut-o values obtained as 28.5, 0.84, and 1.19 with corresponding sensitivity: specicity values as 79%:91%, 79%:82%, and 54%:91%, respectively. Interdependency between parameters was also evaluated. Conclusion: High values of Llyn. Maximum SUV and LLRmax are the main characteristics of lymphoma, metastasis, and sarcoidosis. The diameter of the largest lymph node, SLRmax, and BMLRmax are determined as distinct parameters for distinguishing lymphoma from sarcoidosis. Besides, observed correlation structures amongst some PET/CT parameters were identied as nodal, extranodal, and diuse patterns for three disease groups except sarcoidosis. These ndings extend the knowledge about diagnostic factors based on 18F-FDG PET/CT patterns for DLAP.