Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.28, sa.5, ss.270-273, 2000 (Scopus)
Laryngoschopy and endothracheal intubation are known to increase blood pressure and heart rate by the release of cathecholamines from the symphathetic nervous system. Our study aimed to evaluate a new partial μ receptor agonistlc analgesic tramadol's effect on this response. This double blinded study was performed on 30 ASA I-II class patients aged between 16-75 years undergoing elective surgery with the approval of ethical committee and the patients. The cases were premedicated with 0.05 mg/kg midazolam IM preoperatively. After standard monitorisatlon (ECG, noninvasive blood pressure, heart rate, SpO2) either 3 mg/kg tramadol or saline were administered. Standard anaesthesia induction and maintenance were made 5 minutes after this drug, (5 mg/kg thiopenthone, 0.1 mg/kg vecuronium, % 50-50 N2O2, % 1 isoflurane). Measurements were performed: In the beginning (t0), 5 minutes after tramadol (t1), 1 minute after thiopenthone (t2), 1 and 5 minutes after the endotracheal intubation (t3,t4). Statistical comparisons were made by Tukey Kramer multiple comparison test, ANOVA and x2 tests. In each of the two groups t3 values (systolic, diastolic blood pressures, and rate pressure product) were significantly increased. Only the heart rate of the tramadol group at the same time interval didn't change. Finally it is concluded that 3 mg/kg tramadol IV is not depressing the hacmodynamic response against the endothracheal intubation when administered 5 minutes before anaesthesia induction.