The protective effects of adalimumab on intestinal injury induced with infrarenal aortic occlusion İnfrarenal aort oklüzyonu ile oluşan intestinal hasarında adalimumab’ın koruyucu etkisi

PERGEL A., Tumkaya L., DEMİRAL G., Çolakoğlu M. K., KALCAN S., ÖZDEMİR A., ...Daha Fazla

Ulusal Travma ve Acil Cerrahi Dergisi, cilt.26, sa.3, ss.366-372, 2020 (SCI-Expanded, Scopus, TRDizin) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.14744/tjtes.2019.59607
  • Dergi Adı: Ulusal Travma ve Acil Cerrahi Dergisi
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.366-372
  • Anahtar Kelimeler: Adalimumab, Intestinal injury, Ischemia, Oxidative stress, Rat, Reperfusion
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Samsun Üniversitesi Adresli: Hayır

Özet

BACKGROUND: The present study aims to observe the effects of ischemia-reperfusion (IR) on small intestines at a molecular level and to prospectively assess the potential preventive role of adalimumab (ADA) and antioxidants. METHODS: A total of 24 male Sprague–Dawley rats were randomly divided into three groups–a control group, an IR group and an IR+ADA group. RESULTS: Although there was no change in SOD levels in the small bowel tissue of the IR group, we observed increased malondi-aldehyde (MDA) levels and increased numerical density of caspase-3 and TNF-α positive enterocytes p=0.00 and p=0.00, respectively). We also observed that IR caused the degeneration of villus crypt structures. CONCLUSION: We found that ADA treatment reduced MDA levels and decreased the numerical density of caspase-3 and TNF-α positive enterocytes compared to the IR group (p=0.00; p=0.011; p=0.00, respectively). We conclude that ADA can be beneficial in preventing intestinal injury that arises from IR.