Akademik Veri Yönetim Sistemi
Scandinavian Journal of Clinical and Laboratory Investigation, cilt.81, sa.1, ss.34-38, 2021 (SCI-Expanded, Scopus)
Among the most common causes of nasal congestion in childhood is adenoid hypertrophy (AH) which leads to hypoxia. In this study, we studied plasma concentrations of hypoxia induced factor-1α (HIF-1α) in children undergoing adenoidectomy. The study included a total of 86 participants: 39 patients with AH and 47 healthy individuals. Serum HIF-1α levels (ng/mL) were measured by ELISA. HIF-1α concentrations were compared to the adenoid-nasopharyngeal ratio (ANR) of patients with AH, as recorded in the medical records. We found significantly higher concentrations of HIF-1α (0.30 ± 0.47 ng/mL) in patients with AH as compared to healthy controls (0.24 ± 0.07 ng/mL, p =.011). HIF-1α levels were not significantly different regarding gender between patients with AH (p =.77) and in the control group (p =.97). In patients with AH, there was a moderately significant positive correlation between HIF-1α levels and Hb (p =.000), (correlation coefficient r = 0.542). There was a positive correlation between HIF-1α and ANR in patients with AH (p =.005, r = 0.439). This study indicates that AH increases HIF-1α levels. We also observed a moderately significant positive correlation between HIF-1α and ANR in patients with AH. HIF-1α levels are a potential biomarker for hypoxia in patients with AH.