Akademik Veri Yönetim Sistemi
Pediatrics International, cilt.54, sa.6, ss.816-819, 2012 (SCI-Expanded, Scopus)
Background: In order to better understand the pathogenesis of risk of future sub-/infertility in children with unde-scended testes (UDT), we designed this prospective study to examine the oxidative stress, inflammatory response and autoimmunity in children with UDT. We examined the concentrations of malondialdehyde (MDA), interleukin-6 (IL-6) and antisperm antibodies (ASA) in children with UDT and healthy controls. Methods: The UDT group consisted of 88 boys (aged 1-14 years, unilateral in 67 and bilateral in 21 cases), and 44 boys with normal descended testes served as a control group. Clinical evaluation revealed no testicular or other system abnormalities. MDA was used as lipid peroxidation index. IL-6 levels were measured using a commercial enzyme-linked immunosorbent assay kit. ASA was determined with an anti-human spermatozoa immunoglobulin G test. Results: Mean age values 1 SD were 4.6 1 3.2 in the UDT group and 4.7 1 3.4 in the control group (P = 0.872). MDA and IL-6 results for the UDT and control groups were significantly different (P = 0.003 and P = 0.019, respectively), but those for ASA were not (P = 0.473). The mean MDA and IL-6 values were significantly higher in bilateral cases than the respective values in the unilateral cases (MDA: 4.03 1 3.68 vs 3.49 1 5.22, P = 0.015; IL-6: 7.70 1 6.86 vs 3.48 1 6.50, P = 0.001) (P = 0.015). Conclusion: The results indicate that children with UDT are exposed to high levels of oxidative stress and inflammatory reaction. This could negatively affect the future fertility in these children. © 2012 The Authors.