Pain Medicine (United States), cilt.19, sa.10, ss.2069-2076, 2018 (SCI-Expanded, Scopus)
Objective. The purpose of this study was to evaluate the analgesic effect of a prilocaine + bupivacaine combination in patients undergoing periprostatic nerve block (PNB) by comparing its effects with those of prilocaine alone. Design. Single center, single-blind, prospective descriptive study. Subjects. Four hundred patients with transrectal prostate biopsy pain. Methods. The patients in this prospective, randomized controlled study were divided into two groups. The first group received prilocaine during PNB (Group 1), whereas the second received a prilocaine + bupivacaine combination (Group 2). Results. The mean visual analog scale (VAS) scores immediately after biopsy were 2.52±0.7 and 2.53±0.9, respectively (P=0.35). VAS values were significantly lower in Group 2 at one and six hours following the procedure. The most painful part of the biopsy according to many patients was the probe insertion. Conclusions. The prilocaine + bupivacaine combination is an effective analgesic method during prostate biopsies and for one and six hours after prostate biopsy.