Akademik Veri Yönetim Sistemi
Kuwait Medical Journal, cilt.53, sa.3, ss.271-281, 2021 (SCI-Expanded, Scopus)
Objective: Inflammatory bowel disease (IBD) has effects on neural cardiovascular control mechanisms. The aim of this study was to evaluate the effect of IBD status on cardiovascular autonomic functions by measuring heart rate variability (HRV) parameters with a 24-hour holter electrocardiogram recording. Design: A prospective analytical case control study Setting: Yıldırım Beyazıt University Medical Faculty and Ataturk Education and Research Hospital Ankara, Turkey Subjects: Sixty-seven patients with IBD and 51 matched control subjects were included in the study. Intervention: All participants underwent a 24-hour Holter recording to assess HRV parameters. Main outcome measures: The study population was separated into three groups (active disease, remission and control group) to analyze the effect of disease activity status on the HRV parameters. Results: No difference was determined between the IBD and control groups in respect of any HRV parameters. Significant differences were determined between the active IBD patients and the remission group in terms of the HRV measurements of SDNN5, triangular index, AVG, SDVLF and SDdef. The measurements of SDNN and PNN50 were found to be significantly different between the active IBD patients and the control group. Conclusions: The results of this study demonstrated for the first time that the active phase of IBD is associated with cardiac autonomic abnormalities compared to both control group and IBD patients in remission. Patients with IBD should be followed up closely for cardiovascular events as they appear to be at risk for cardiovascular diseases and arrhythmia, particularly during the active phase of the disease.