Akademik Veri Yönetim Sistemi
Turkish Journal of Immunology, cilt.9, sa.1, ss.21-26, 2004 (Scopus)
Rheumatoid arthritis (RA) is the most common autoimmune disease in community but there is no specific and easy diagnostic test. We studied the diagnostic value of Anti-Cyclic Citrullinated Peptide (Anti-CCP) antibody positiveness, which is a new marker of RA. We also tried to determine the relationship between anti-CCP positivity and patients clinically diagnosed with early synovitis (ES). We investigated anti-CCP antibodies in total of 119 patients including 27 RA, 25 Systemic Lupus Erythematosus (SLE), 19 Osteoarthritis (OA), 30 healthy blood donors (HBD) and 18 ES. In addition, Rheumatoid Factor (RF) IgM was studied in all patient serums and the results were compared with anti-CCP antibodies for sensitivity and specificity. A statistically significant difference was found between the patients with RA and without RA for the detection of Anti-CCP positivity ( p<0.0001). Separately, a strong correlation between RA and the existence of anti-CCP (κ= 1). was found. The specificity and sensitivity of Anti-CCP antibodies were found as 98.6% versus 86.4% and 70% versus 60%, respectively when compared with RF-IgM. We concluded that the Anti-CCP positiveness in patients with arthritis suggets its potential usefulness as a marker of diagnosis.