Akademik Veri Yönetim Sistemi
European Journal of Obstetrics and Gynecology and Reproductive Biology, cilt.216, ss.24-26, 2017 (SCI-Expanded, Scopus)
Background The aim of this study is to measure and compare the dynamic thiol and disulphide homeostasis between patients with Uterine Myoma (UM) and healthy subjects. Material and method A total of 54 patients with UM who were diagnosed by transvaginal ultrasonography and 37 age- and body mass index-matched healthy individuals were included in this study. Thiol/disulphide homeostasis was measured by a novel automatic spectrophotometric method. Results The mean serum native thiol, disulphide, and thiol levels were statistically lower in UM group than those in the control group [(284.66 ± 59.41 μmol/L vs. 320.98 ± 56.17 μmol/L, P < 0.0001), (17.27 ± 5.59 μmol/L vs. 22.38 ± 6.93 μmol/L, P < 0.0001) and (319.21 ± 61.69 vs. 365.76 ± 61.46 μmol/L, P < 0.0001), respectively]. There were no statistically significant differences in ratios of the disulphide/native thiol, native thiol/total thiol, and disulphide/total thiol among patients with UM versus healthy control group (P = 0.096, 0.092, 0.092, respectively). Conclusion It was found that the native thiol, total thiol, and disulphide levels in patients with UM decreased while the ratio of native thiol/disulphide remained unchanged.It is necessary to investigate whether these findings have a role in the etiology and clinical course of the UM.